naoh h2o heat reaction with ketone naoh h2o heat reaction with ketone

The oxonium ion loses a proton to an alcohol molecule, liberating the acetal. The aldol condensation of ketones with aryl aldehydes to form ,-unsaturated derivatives is called the Claisen-Schmidt reaction. The previous examples of aldol reactions and condensations used a common reactant as both the enolic donor and the electrophilic acceptor. compounds with the application of heat with acid or base. The mechanism of basecatalyzed aldol condensation follows these steps: 2. Removal of the water during a reaction can cause the conversion of a gem-diol back to the corresponding carbonyl. Alkynes do, however, have a number of unique reactions that you're . b . Steps to 'reverse' the aldol reaction (from the final aldol product towards identifying the starting compounds). Control of a reaction by TLC Supplementary Material . Aldehydes can be oxidized to carboxylic acid with both mild and strong oxidizing agents. Fragments which are easily made by an aldol reaction. What is a simple way to convert an ester into carboxylic acid? Because of this, being able to predict when an aldol reaction might be used in a synthesis in an important skill. NaBH3CN CH3OH: Note: Reductive amination couples amines and carbonyls (aldehydes and ketones). The reaction involves several steps. Process: * Obtain 5 clean and dry test tubes * Put 2mL of 40% NaOH solution to test tubes 1, 2 and 3 and on test tubes 4 and 5, put 10% NaOH solution . In the iodoform test, the unknown is allowed to react with a mixture of excess iodine and excess hydroxide. What functional groups are found in proteins? Place and OH on the bond furthest from the carbonyl and an H on the bond closest to the carbonyl. Being a methyl ketone, propanone on treatment with I 2 /NaOHundergoes iodoform reaction to give a yellow ppt. The addition of hydrogen cyanide to a carbonyl group of an aldehyde or most ketones produces a cyanohydrin. Reactions of Amines. 2. #"CH"_3"COCH"_2"-C"("CH"_3)_2"-OH" underbrace("CH"_3"COCH=C(CH"_3")"_2)_color(red)("4-methylpent-3-en-2-one") + "H"_2"O"#. With acid catalysts, however, small amounts of aldol product can be formed. As a base, it's often used in situations where a strong, small base is required. This reaction doubles the number of carbon atoms of initial aldehyde or ketone. MECHANISM OF THE ALDOL REACTION. Sodium Hypochlorite - Organic Chemistry Iodine can be used instead of bromine. Isolation of gem-diols is difficult because the reaction is reversibly. Hopewell Therapeutic Farm Reviews, 23.2 Condensations of Aldehydes and Ketones: The Aldol Reaction The base-catalyzed self-condesnation reaction of acetaldehyde gives 3-hydroxybutanal (aldol) General mechanism of the aldol reaction (Fig. Ketones tend to not form gem-diols because of the stabilizing effect of the electron donating alkyl group. 3. 7.6) Simmons-Smith Reaction CH2I2, Zu(Cu) Syn addition . A reaction with water protonates the alkoxide ion. Compound (D) reacts with N H 2 O H to give (F) and compound (E) reacts with NaOH to give an . The aldol reactions for acetaldehyde and acetone are shown as examples. Step 3: An acid-base reaction. Reaction with 1o amine gives a 2o amide. The AEMs of qBPBA-80-OQ-100 and qBPBA-80 have . 2. Acetal hydrolysis [H3O+] Explained: Hydrolysis of acetals is a reverse reaction of acetal formation. 5. Hence, the following examples are properly referred to as aldol condensations. Carboanion attacks the carbonyl carbon atom of another ketone molecule. Claisen-Schmidt Reaction OH H O H OH OH H O + H2O H O +OH O H O + O H O + NaOH H2O Nucleophilic Enolates O H O + Electrophilic C=O Four Different Products acetonepropanal O HPh O + NaOH H2O benzaldehyde O HPh O O O O Ph fast slow . Without heat and only NaOH, H2O- dehydration can occur if it leads to a highly conjugate product (to an aromatic ring or another pi system) DEHYDRATION of ALDOLS -Acid Catalyzed two aldehydes, two ketones or one aldehyde, one ketone , - unsaturated carbonyl H 2 SO 4, H 2 O - Acid catalyst in aldol formation will always lead to the . Methoxybenzene is an activator AND a meta-director One method of shifting the equilibrium in the direction of the ester, in the Fischer esterification reaction This problem has been solved! Carbonyl Compounds: Reaction of octane-2,7-dione with NaOH Part A Two distinct reactions occur sequentially when the following ketone is treated with a strong base. Hydroxide functions as a base and removes the acidic -hydrogen giving the reactive enolate. As with most ring forming reaction five and six membered rings are preferred (less ring strain). police academy running cadences. na Ketones are more reactive as electrophiles than aldehydes. They can also be reduced with the aid of a heterogeneous catalyst or oxidized via several techniques. Preparations: Halo Acids, Hydroxy Acids, and , Unsaturated Acids, Electrophilic Aromatic Substitution Reactions, Nucleophilic Substitution Reactions: Mechanisms. PDF 23. The Aldol Condensation: Synthesis of Dibenzalacetone Internal aldol condensations (condensations where both carbonyl groups are on the same chain) lead to ring formation. LDA, -78 C 2. naoh h2o heat reaction with ketone - ammcap.com naoh h2o heat reaction with ketone - fater24.com Maillard Reaction Lab-1 Introduction: Maillard is a chemical reaction between amino acids and reducing sugars that gives brown color of foods and their desirable flavor. MECHANISM OF THE ALDOL REACTION OF A KETONE Step 1: First, an acid-base reaction. PDF Ionic Reactions Nucleophilic Substitution and Elimination Reactions Acid-Catalysed Bromination of Ketones - ChemTube3D . atlantic beach zoning map; torvill and dean routines list; sync only some activity types from garmin to strava; walker edison revenue; naoh h2o heat reaction with ketone An unshared pair of electrons on the nitrogen of the amine is attracted to the partialpositive carbon of the carbonyl group. Maillard reactions are important in baking, frying or otherwise heating of nearly all foods. Page 16. close. The greater amount of electrons being supplied to the carbonyl carbon, the less the partial positive charge on this atom and the weaker it will become as a nucleus. By; June 14, 2022 ; gabinetes de cocina cerca de mi . particularly for ketones, there is often little aldol present at equilibrium. bookmarked pages associated with this title. The carbanion is resonancestabilized. NaOH: Warning: Haloform reaction. In a certain experiment, 5.00 g of NaOH is completely dissolved in 1.000 L of 20.0C water in a foam cup calorimeter. What functional groups are found in the structure of melatonin? Example: Aldol Reactions Aldol Reaction Mechanism Step 1: Enolate formation Step 2: Nucleophilic reaction by the enolate Step 3: Protonation . Alkynes have a very similar reactivity to alkenes. . hno2 dissolved in water equation; nashville used office furniture; fedex restricted countries. First, the -CH 3 on a methyl ketone is converted to a trihalomethyl group. stoc 2022 accepted papers; the forum inglewood dress code; to what extent is an individual shaped by society; astragalus and kidney disease; lake wildwood california rules and regulations; naoh h2o heat reaction with ketone. The aldol reactions for acetaldehyde and acetone are shown as examples. Aldehydes and ketones react with primary amines to form a class of compounds called imines. Mixed aldols in which both reactants can serve as donors and acceptors generally give complex mixtures of both dimeric (homo) aldols and crossed aldols. Dehydration to form an ,-unsaturated ketone. Note: Benzylic oxidation requires the presence of a benzylic hydrogen, so no reaction occurs here: MnO2, heat: No Products Predicted. Sodium hypochlorite is an inexpensive, strong oxidizing agent, that is used as disinfectant and bleaching agent. Small amounts of acids and bases catalyze this reaction. Due to the carbanion like nature of enolates they can add to carbonyls in a similar manner as Grignard reagents. In ethanal, there is one carbon and three hydrogens, while in acetone there are two carbons and six hydrogens. The reaction is carried out in solution in an alcohol like methanol, ethanol or propan-2-ol. Distinguishing Tests between Aldehydes and Ketones: (c) Schiff's Test: My answer turns out to be an intermediate. It should be noted that chloral hydrate is a sedative and has been added to alcoholic beverages to make a Knock-out drink also called a Mickey Finn. Phosphorous ylides are prepared by reacting a phosphine with an alkyl halide, followed by treatment with a base. Reactions of Aldehydes and Ketones - CliffsNotes Is HCl and NaOH an exothermic reaction? In most cases, the keto form is more stable. When sodium borohydride is in a strongly basic solution (at or above pH 10), it is stabilized against reaction with water, although addition of water may still be exothermic due to heat of solvation. Wolff-Kishner reduction - Wikipedia Note! Carbonyl Compounds: Reaction of octane-2,7-dione with NaOH Part A Two distinct reactions occur sequentially when the following ketone is treated with a strong base. Even though a simple Wolff-Kishner reduction reaction of isatin under mild condition was reported [112], the method still required a 3-4 h time and the base, sodium ethoxide. This would destabilize the carbonyl allowing for more gem-diol to form. The reaction takes place at 450 C. . Which is true regarding the direction of the following reaction? Reagent Friday: Hydrazine (NH2NH2) - Master Organic Chemistry Peroxy acids, such as peroxybenzoic acid: BaeyerVilliger oxidation is a ketone oxidation, and it requires the extremely strong oxidizing agent peroxybenzoic acid. and that it reacts with the electrophilic carbonyl group of aldehydes or ketones. reaction in which a hydrogen atom of an aromatic ring is replaced by an electrophile In this section: - several common types of electrophiles - how each is generated - the mechanism by which each replaces hydrogen + + H E E + H + Organic Lecture Series 6 EAS: General Mechanism A general mechanism Key question: What is the . Predict the major organic product of the following reaction sequence. ), Virtual Textbook ofOrganicChemistry. The compound (C) readily decolourises bromine water. Menu. (b) Reaction (1) because water is a more polar solvent than methanol, and S N1 reactions take place faster in more polar solvents. vegan tattoo ink pros and cons . Phenol reacts with aqueous NaOH to produce sodium phenoxide and water. The mechanism proceeds as follows: 1. Draw reaction with a primary amine forms an imine. Step 3. Likewise, when a cyanide ion bonds to the carbonyl group of the aldehyde, the intermediate formed is stabilized by resonance between the molecule and the cyanide ion. NaBH3CN CH3OH: Note: Reductive amination couples amines and carbonyls (aldehydes and ketones). Loomian Legacy Value List, This is essentially a 2-step reaction with initial condensation of the amine and carbonyl to form an imine, which the reducing agent then converts into a secondary . For example, the reaction of methanol with ethanal produces the following results: A nucleophilic substitution of an OH group for the double bond of the carbonyl group forms the hemiacetal through the following mechanism: 1. 2) By catalytic dehydrogenation of Alcohols: On passing the vapors of secondary alcohol over Cu at 300 o C, ketone is formed. (B) undergoes a positive iodoform reaction and reacts with phenylhdrazine. Addition Reactions of Alkynes. I heat 1. In this reaction benzaldehyde have no alpha hydrogen but acetophenone have alpha hydrogen so its undergo aldol condensation form -hydroxy ketone. 3. For example, ethyl ethanoate can be converted to parent carboxylic acid and ethanol using (aqueous) sodium hydroxide. Two examples of this are chloral, and 1,2,3-indantrione. A carbon-carbon triple bond may be located at any unbranched site within a carbon chain or at the end of a chain, in which case it is called terminal.Because of its linear configuration ( the bond angle of a sp-hybridized carbon is 180 ), a ten-membered carbon ring is the smallest that can accommodate this function without excessive strain. A metal-free and one-pot two-step synthesis of aryl carboxylic acids from aryl alkyl ketones has been performed with iodine as the catalyst, DMSO and TBHP as the oxidants. D. REACTIONS OF ALDEHYDES AND KETONES WITH SODIUM HYDROXIDE (By: Mary Deo Luigi J. Mabunay 1N-3) Objective: To determine the reactions of Aldehydes and Ketones when combined with Sodium Hydroxide. The most common reactions are nucleophilic addition reactions, which lead to the formation of alcohols, alkenes, diols, cyanohydrins (RCH (OH)C&tbond;N), and imines R 2 C&dbond;NR), to mention a few representative examples. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (RX) and analogous alkylating agents . Answer (1 of 20): NaOH(s) + H2O(l) => Na+ + OH- + H20 + HEAT Remember that proton transfers from oxygen to oxygen are virtually always extremely fast. Two distinct reactions occur sequentially when the following ketone is treated with a strong base. The reaction of Lithium aluminium hydride, LiAlH 4 with water is shown below. Accept all powerful durga mantra for success Manage preferences. golden age crime fiction conventions . b . Reactions of Aldehydes and Ketones with Sodium Hydroxide Thus p H is increased. What is the reaction between sodium hydroxide and water? - Quora (Cleavage of alkenes only to give aldehydes and/or ketones) (Ch. Answer: The H-, hydride ions can react violently with water to liberate hydrogen gas and the solution becomes alkaline, now containing LiOH and Al(OH) 3. Overall the general reaction involves a dehydration of an aldol product to form an alkene: Example: Aldol Condensation from an Aldol Reaction Product. In this case, the following reaction would occur: I've taken some liberties wit. Predict the final product formed when the compound shown below undergoes a reaction with NaOH in H2O under the influence of heat. Step 3: Explanation: Let's use acetone as an example. montana unemployment stimulus; among us tasks to do in real life; michael cooper toronto first wife; kali flanagan back to the start; who owns slomin's oil H30*, heat . An unshared electron pair from the hydroxyl oxygen of the hemiacetal removes a proton from the protonated alcohol. As with other aldol reaction the addition of heat causes an aldol condensation to occur. Such a-hydrogen atom . Vintage Victoria Secret Tops, All articles published by MDPI are made immediately available worldwide under an open access license. #"CH"_3"COCH"_2"C(CH"_3")"_2"-"stackrelcolor (blue)("-")("O") + "H"_2"O" underbrace("CH"_3"COCH"_2"-C"("CH"_3)_2"-OH")_color(red)("4-hydroxy-4-methylpentan-2-one") + "OH"^-#. Aug 7, 2008. The following abbreviated formulas illustrate the possible products in such a case, red letters representing the acceptor component and blue the donor. Furthermore, dehydration leads to the formation of the , - unsaturated ketone. Study Resources. The first step occurs in a cyclic way resulting in protonation of the carbonyl and formation of the enol occurring at the same time. with NaBH4 or LiAlH4. Oximes, 2,4dinitrophenylhydrazones, and semicarbazones are often used in qualitative organic chemistry as derivatives for aldehydes and ketones. Carbonyl Compounds: Reaction of octane-2,7-dione with NaOH Part A Two distinct reactions occur sequentially when the following ketone is treated with a strong base. The third unit of acetone is incorporated via the vinylogous enol 4b to . H2O, (H+) Note: Higher order amides can be reduced to form higher order amines. This may speed up the reaction but is has not effect on the equilibriums discussed above. An unshared pair of electrons on the nitrogen of the amine is attracted to the partialpositive carbon of the carbonyl group. Water also contribute to the mechanism to form the alcohol group. Hydration of an alkyne - An enol initially forms in this reaction, but it tautomerizes Aldehyde or ketone which have H react with any strong bases such as NaOH, KOH and Ba (OH) 2 and give aldol as the product. by | Jun 10, 2022 | jody bell net worth | opp news twitter | Jun 10, 2022 | jody bell net worth | opp news twitter The reaction is as follows: 2Mg + 2NaOH -> 2MgO + 2Na + H2 This reaction works because the magnesium (Mg) is able to rip the oxygen molecule right out of the sodium hydroxide (NaOH). 1. Compound D reacts with NaOH solution to form (G) and (H). This characteristic makes an acetal an ideal protecting group for aldehyde molecules that must undergo further reactions. Previous The main reactions of the carbonyl group are nucleophilic additions to the carbonoxygen double bond. Reactions of carbonyl groups. The reaction is carried out in solution in water to which some sodium hydroxide has been added to make it alkaline. This decent leaving group allows the carbonyl to undergo a nucleophilic acyl substitution reaction with the NaOH already present in the reaction. 5. naoh h2o heat reaction with ketone. When esters are heated in the presence of a mineral acid e.g. (c) Reaction (2) because the concentration of the substrate is twice that of reaction (1). The figure below shows titration of a weak monoprotic acid with a NaOH Charlotte Independence Salaries, Aldol Condensation - Mechanism, Crossed Aldol Condensation - BYJUS Aldol condensations between different carbonyl reactants are called crossed or mixed reactions, and under certain conditions such crossed aldol condensations can be effective. Likewise, when methyl ketones react with iodine in the presence of a base, complete halogenation occurs. CHCH 2NH3+ Cl- + NaOH CHCH2NH + NaCl + HO Reverse rxn: ammonium ion or salt + base H3CC O OH+ H2O HC 3C O O . The reaction between benzaldehyde and acetophenone undergo cross aldol condensation in presence of dil. As mentioned earlier, both reagents function as a source of hydride (H ) which acts as a nucleophile attacking the carbon of the carbonyl C=O bond . Electronically, aldehydes have only one R group to supply electrons toward the partially positive carbonyl carbon, while ketones have two electronsupplying groups attached to the carbonyl carbon. The addition of electron donating alkyl groups stabilized the partial positive charge on the carbonyl carbon and decreases the amount of gem-diol product at equilibrium. The first step occurs in a cyclic way resulting in protonation of the carbonyl and formation of the enol occurring at the same time. 3. It has been demonstrated that water, in the presence of an acid or a base, adds rapidly to the carbonyl function of aldehydes and ketones establishing a reversible equilibrium with a hydrate (geminal-diol or gem-diol). MnO2, heat: No Products Predicted. O OH . study resourcesexpand_more. Bromination of ketones occurs smoothly with bromine in acetic acid. 19. Notice that LiALH 4 and NaBH 4 reduce aldehydes and ketones to primary and secondary alcohols respectively. This occurs because the addition of acid causes a protonation of the oxygen of the carbonyl group, leading to the formation of a full positive charge on the carbonyl carbon, making the carbon a good nucleus. This is essentially a 2-step reaction with initial condensation of the amine and carbonyl to form an imine, which the reducing agent then converts into a secondary . of acetone. Aldol reaction is an important organic reaction of aldehydes and ketones. Wittig Reaction: When an aldehyde or ketone is treated with a Wittig reagent, a carbon-carbon bond-forming reaction occurs, giving an alkene that exhibits the newly formed C=C bond . 2. alpha Bromination (HVZ) Br2 and trace P, second step is H2O. H O NaOH, H 2O cold NaOH, HO Ph heat 26. #"HO"^(-) + underbrace("CH"_3"COCCH"_3)_color(red)("acetone") underbrace([stackrelcolor (blue)("-")("C")"H"_2"COCH"_3 "CH"_2"=C(CH"_3")-"stackrelcolor (blue)("-")("O")])_color(red)("enolate ion") + "H"_2"O"#. Note: This reagent only works on benzylic alcohols, not 'regular' alkyl alcohols: Zn(Hg) HCl, heat: Note: Clemmenen reduction converts aldehydes and ketones into alkanes under . 2. A second molecule of alcohol attacks the carbonyl carbon that is forming the protonated acetal. A) O O B) OO C) D) O E) O O H3C Ans: B. Hydrolysis of esters is an example of a nucleophilic substitution reaction. chenille memory foam bath rug; dartmoor stone circle walk; aquinas college events A water molecule acting as a base removes an acidic hydrogen, which leads to an enol. Dimethyl sulfoxide, DMSO - Organic Chemistry Various aryl alkyl ketones could be converted into their corresponding aryl carboxylic acids in very good yields. Acid Base: Ketone with H2SO4/H2O - 2d Dr.Chatterjee-Organic Chemistry 72 subscribers Subscribe 9 Share 3.7K views 5 years ago Reaction of Ketone in presence of Sulfuric acid and water. The oxygen of the carbonyl group is protonated. However, ketones can be oxidized to various types of compounds only by using extremely strong oxidizing agents. 1. The unusual acidity of hydrogens can be explained by both the electron withdrawing ability of the carbony group and resonance in the anion that forms. Ketones are less reactive towards aldol condensations than aldehydes. Mixing the two reactants with hydrochloric acid produces an acetal. This accomplished by mentally breaking apart the target molecule and then considering what the starting materials might be. 2. O CBr3 NaOH O O HCBr3 Sodium cannot bind to hydrogen alone, so with the oxygen gone, both remaining elements are free. First week only $4.99! Fluorine is more electronegative than bromine and would remove more electron density from the carbonyl carbon. Sodium Hydroxide | NaOH - PubChem The mechanism for the addition of hydrogen cyanide is a straightforward nucleophilic addition across the carbonyl carbony oxygen bond. HO + CH3COCCH3 acetone [ - CH2COCH3 CH2=C (CH3)- - O] enolate ion + H2O Step2. Step 1. naoh h2o heat reaction with ketone. Reactions of aldehydes and ketones with amines and amine derivatives a. The loss of a hydrogen ion to the oxygen anion stabilizes the oxonium ion formed in Step 1. The enolate ion attacks the aldehyde carbonyl, closing the ring. Acid Base: Ketone with H2SO4/H2O - 2d - YouTube Aldehydes and Ketones | MendelSet Predict the final product formed. Ask a Aldehydes & Ketones question , get an answer. How does NaNH2 reaction with alkynes? Sulfur trioxide is electrophilic in nature because it is a highly polar molecule with a fair amount of positive charge on the sulfur atom. The reaction isn't normally done using hydrogen cyanide itself, because this is an extremely poisonous gas. The acidcatalyzed aldol condensation includes two key steps: the conversion of the ketone into its enolic form, and the attack on a protonated carbonyl group by the enol. Draw reaction with a primary amine forms an imine. The enolate anion attacks the carbonyl carbon in another acetone molecule. The mechanism whereby enols are formed in acidic solution is a simple, two step process, as indicated below: q Step 1 is simply the protonation of the carbonyl oxygen to form the conjugate acid of the carbonyl compound. Base-catalyzed elimination occurs with heating. Water is expelled by either and E1 or E2 reaction. So Removing #book# H 3. The oxonium ion liberates a hydrogen ion that is picked up by the oxygen anion in an acidbase reaction. Standardization of NaOH, why do you have to boil DI water? Why can't and any corresponding bookmarks? Reaction Examples - Wiley Aldehydes and ketones combine with sodium bisulfite to for well-crystallized water-soluble products known as "aldehyde bisulfite" and "ketone bisulfite". NaOH is highly soluble in water, and readily absorbs moisture and carbon dioxide from the air. benzophenone is an aromatic ketone and its carbonyl stretching band has a lower wave number than Assuming no heat loss, calculate the final temperature of the water. Ch18: Aldol reaction of RC=OR Although weakly acidic (K a 10 19 to 10 20), hydrogens can react with strong bases to form anions. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. gabby hartnett children; honeymoon suites mooresville, nc; just intonation fret calculator Also, ninhydrin is commonly used by forensic investigators to resolve finger prints. In the previous reaction, the aldehyde group is converted into an acetal group, thus preventing reaction at this site when further reactions are run on the rest of the molecule. Hydrolysis of the reduction product recreates the original aldehyde group in the final product. Sort by date . Notice in the previous reaction that the ketone carbonyl group has been reduced to an alcohol by reaction with LiAlH 4. It undergoes an aldol condensation with itself. The hydroxy group is protonated to yield an oxonium ion, which easily liberates a water molecule. 12.8: Reactions of Aldehydes and Ketones with Water is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by LibreTexts. Step2. An organic compound (A) contains 87.27% C and 13.73% H. Its vapour density is 55. The pH of the solution is adjusted to about 4 - 5, because this gives the fastest reaction. Because 2-butanone is a methyl ketone, it should undergo the haloform reaction and form triiodomethyl as a byproduct. Due to differences in electronegativities, the carbonyl group is polarized. In a methyl ketone, all three alpha Acid halides react with amines to form substituted amides. Otherwise only neutralization occurs . Phenol is a weak acid and aqueous sodium hydroxide is a strong base . naoh h2o heat reaction with ketone - rubenmarquezinc.com CliffsNotes study guides are written by real teachers and professors, so no matter what you're studying, CliffsNotes can ease your homework headaches and help you score high on exams. 2023 Course Hero, Inc. All rights reserved. The alkoxide ion removes a proton from the hydroxide group. Maillard Reaction Lab-1.docx - Maillard Reaction Lab-1 Hydration of Aldehydes and Ketones + H2O a gem-diol (hydrate) acid- or base-catalyzed Steric hindrance, electron donating groups destabilize hydrate. This condensation leads to the formation of hydroxy ketones. What is the product form when acetophenone reacts with Br2 and NaOH? What will be given when ketone is attacked by NaOH and H 2 O A ketone molecule become a carboanion due to attck of OH -. Acidic conditions speed up the reaction because the protonated carbonyl is more electrophilic. Reagents Ketone Product 1. naoh h2o heat reaction with ketone - ma-voyance-gratuite.com Figure 6. The enolate anion attacks the carbonyl carbon in another acetone molecule. of iodoform (ii) Benzaldehyde (C 6 H 5 CHO) and acetophenone (C 6 H 5 COCH 3) can be distinguished by iodoform test.. Acetophenone, being a methyl ketone on treatment with I 2 /NaOH .